JACC Heart Failure Editor's Update - May 2018
HEART FAILURE RESEARCH at ACC.18
Heart failure research was well represented at ACC.18. The Eugene Braunwald Keynote Lecture on “The Relationship Between Heart Failure and Type 2 Diabetes” by Dr. John J.V. McMurray, Professor of Cardiology at the University of Glasgow, was excellent and insightful. The session began with each Editor-in-Chief of the JACC journals briefly presenting what we identified as our top papers from 2017, which included my presentation on The Best of JACC Heart Failure: Practice Changing Research. Below is a list of papers our Associate Editor team selected as most impactful among the many outstanding papers published in 2017.
- Body Weight Change During and After Hospitalization for Acute Heart Failure: Patient Characteristics, Markers of Congestion, and OutcomesFindings From the ASCEND-HF Trial
Andrew P. Ambrosy, Lukasz P. Cerbin, et al
- Associations Between Short or Long Length of Stay and 30-Day Readmission and Mortality in Hospitalized Patients With Heart Failure
Maneesh Sud, Bing Yu, et al
- Decreased Mortality With Beta-Blockers in Patients With Heart Failure and Coexisting Atrial FibrillationAn AF-CHF Substudy
Julia Cadrin-Tourigny, Azadeh Shohoudi, et al
- Body Mass Index and Cardiorespiratory Fitness in Mid-Life and Risk of Heart Failure Hospitalization in Older AgeFindings From the Cooper Center Longitudinal Study
Ambarish Pandey, William K. Cornwell, et al
- Targeted Metabolomic Profiling of Plasma and Survival in Heart Failure Patients
David E. Lanfear, Joseph J. Gibbs, et al
- Risk Assessment and Comparative Effectiveness of Left Ventricular Assist Device and Medical Management in Ambulatory Heart Failure PatientsThe ROADMAP Study 2-Year Results
Randall C. Starling, Jerry D. Estep, et al
- The Affordable Care Act Medicaid Expansion Correlated With Increased Heart Transplant Listings in African-Americans But Not Hispanics or Caucasians
Khadijah Breathett, Larry A. Allen, et al
- Discordant Perceptions of Prognosis and Treatment Options Between Physicians and Patients With Advanced Heart Failure
Amrut V. Ambardekar, Jennifer T. Thibodeau, et al
2017 YOUNG AUTHOR WINNERS
- A New Clinically Applicable Measure of Functional Status in Patients With Heart FailureThe 60-Foot Walk Test
Kristie M. Harris, MS, The Ohio State University
Mentor: David S. Krantz, PhD, Uniformed Services University of the Health Sciences
- A Novel Rehabilitation Intervention for Older Patients With Acute Decompensated Heart FailureThe REHAB-HF Pilot Study
Gordon R. Reeves (right), MD, MPT, Sidney Kimmel Medical College at Thomas Jefferson University
Mentor: David J. Whellan (left), MD, MHS, Thomas Jefferson University
SIMULTANEOUS PUBLICATIONS FROM ACC.18
- Sudden Death in Heart Failure with Preserved Ejection Fraction: A Competing Risks Analysis from the TOPCAT Trial
Muthiah Vaduganathan, Brian L. Claggett, et al
Sudden death was shown to account for approximately 20% of deaths in HFpEF, with male gender and insulin-treated diabetes predicting higher risk for sudden death or aborted cardiac arrest. The data from this study may guide future efforts to prevent sudden death in HFpEF.
- Natriuretic Peptides as Biomarkers of Treatment Response in Clinical Trials of Heart Failure
Muthiah Vaduganathan, Brian Claggett, et al
This research showed that therapy-related changes in natriuretic peptides (NPs) appeared to be modestly correlated with longer-term therapeutic effects on hospitalization for heart failure, but not with effects on all-cause mortality, suggesting caution regarding the use of NPs in phase II trials for decision-making regarding phase III trials.
- Will biomarkers succeed as a surrogate endpoint in heart failure trials?
James L. Januzzi
An Editorial Comment which suggests that additional studies are necessary before cardiac biomarkers can be used as acceptable endpoints.
I have to ask Jim Januzzi, Mike Felker and their biomarker colleagues - why hasn't the heart failure field advanced further with biomarkers as surrogate endpoints (like LDL) and have we advanced at all with results such as the GUIDE-IT study? Let's hear from you on this topic.
I look forward to highlighting more of our excellent publications and highlighted topics in next month's issue.