Table 1

Baseline Characteristics: Comparisons Between FIX-HF-5C and FIX-HF-5 Subgroup (With EF ≥25%) Cohorts by Group and Pooled

Control GroupCCM GroupControl Merged
(n = 198)
CCM Merged (n = 191)p Value
(Control vs. CCM, Combined)
FIX-HF-5 Subgroup
(n = 112)
FIX-HF-5C
(n = 86)
p ValueFIX-HF-5 Subgroup
(n = 117)
FIX-HF-5C
(n = 74)
p Value
Age, yrs60 ± 1263 ± 110.0859 ± 1263 ± 110.01161 ± 1260 ± 120.51
Male83/112 (74.1)68/86 (79.1)0.5083/117 (71.0)54/74 (73.0)0.869151/198 (76.3)137/191 (71.3)0.34
White ethnicity81/112 (72.3)61/74 (70.9)0.8788/117 (75.2)55/74 (74.3)1.0000142/198 (71.72)143/191 (74.87)0.49
Ischemic CHF etiology77/112 (68.8)51/86 (59.3)0.1884/117 (71.8)46/74 (62.2)0.2026128/198 (64.65)130/191 (68.06)0.52
Prior MI66/112 (58.9)51/86 (59.3)1.0078/117 (66.7)36/74 (48.7)0.0157117/198 (59.09)114/191 (59.69)0.92
Prior PT/ICD88/112 (78.6)73/86 (84.9)0.2893/117 (79.5)65/74 (87.8)0.1702161/198 (81.31)158/191 (82.72)0.79
Diabetes58/112 (51.8)42/86 (48.8)0.7757/117 (48.7)38/74 (51.4)0.7675100/198 (50.51)95/191 (49.74)0.92
NYHA functional class IV15/112 (13.4)8/86 (9.3)0.508/117 (6.8)10/74 (13.50)0.135023/198 (11.62)18/191 (9.42)0.51
QRS duration, ms101.1 ± 13.8103.6 ± 12.10.1899 ± 14103 ± 130.13102 ± 13101 ± 140.24
LVEF, % (core laboratory)32 ± 433 ± 50.1331 ± 433 ± 60.01232 ± 532 ± 50.89
LVEDD, mm (core laboratory)56 ± 1160 ± 70.00357 ± 1058 ± 70.2558 ± 958 ± 100.76
MLWHFQ56 ± 2457 ± 230.7260 ± 2356 ± 230.2557 ± 2359 ± 230.36
6MHW, m324 ± 91324 ± 900.97326 ± 84317 ± 880.48324 ± 91322 ± 860.08
CPX (core laboratory)
 Peak Vo2, ml/kg/min14.8 ± 3.215.4 ± 2.80.2014.6 ± 3.015.5 ± 2.60.03615.0 ± 3.015.0 ± 2.90.73
 Exercise time, min11.7 ± 3.510.6 ± 3.10.02511.3 ± 3.211.4 ± 3.10.7711.2 ± 3.311.3 ± 3.10.74
Physical examination
 Weight, kg96 ± 23100 ± 230.2392 ± 22100 ± 210.02798 ± 2395 ± 220.20
 Height, cm173 ± 10174 ± 90.44173 ± 9175 ± 1020.24174 ± 10174 ± 90.98
 BMI, kg/m232 ± 733 ± 70.3631 ± 732 ± 60.0532 ± 731 ± 70.15
 Resting HR, beats/min73 ± 1276 ± 140.0971 ± 1274 ± 110.03975 ± 1372 ± 120.07
Blood pressure
 Systolic117 ± 18126 ± 190.0007119 ± 18123 ± 180.12121 ± 19120 ± 180.71
 Diastolic71 ± 1174 ± 110.02370 ± 1174 ± 110.05872 ± 1172 ± 110.65

Values are mean ± SD or n/N (%). Bold values indicate statistical significance.

6MHW = 6-min hall walk test; BMI = body mass index; CHF = chronic heart failure; CPX = cardiopulmonary exercise stress test; HR = heart rate; ICD = implanted cardiac-defibrillator; LVEDD = left ventricular end-diastolic diameter; LVEF = left ventricular ejection fraction; MI = myocardial infarction; MLWHFQ = Minnesota Living With Heart Failure Questionnaire; NYHA = New York Heart Association; PT = pacing therapy.

  • p value from 2-sample Student's t-test or Fisher exact test as appropriate.