Table 4

Association Between Time of Presentation (Off Hours vs. Regular Hours) and Clinical Outcomes Using Alternate Group Definitions

Raw Event Rate (Number or Events/Sample Size)UnadjustedAdjusted
Off HoursRegular HoursOdds Ratio (95% CI)p ValueOdds Ratio (95% CI)p Value
Dyspnea relief at 24 h§1.19 (1.08–1.31)<0.0011.18 (1.07–1.30)<0.001
30-day all-cause mortality/all cause rehospitalization (%)335/2,216 (15.1)732/4,925 (14.9)0.99 (0.86–1.14)0.9041.05 (0.91–1.22)0.507
30-day all-cause mortality (%)80/2,216 (3.6)193/4,925 (3.9)0.89 (0.68–1.16)0.3870.88 (0.67–1.17)0.392
30-day all-cause rehospitalization (%)262/2216 (11.8)564/4,925 (11.5)1.01 (0.86–1.18)0.9011.07 (0.91–1.26)0.401
180-day all-cause mortality (%)267/2,216 (12.1)633/4,925 (12.9)0.90 (0.78–1.04)0.1710.92 (0.80–1.07)0.291

Values are n/N (%), unless otherwise indicated.

Abbreviations as in Tables 1 and 3.

  • Regular hours were defined as 7 am to 7 pm, Monday through Friday, and off hours as 7 pm to 7 am, Monday through Friday and weekends.

  • Unadjusted model controls for region.

  • Adjusted model controls for region age, gender, BMI, EF, NYHA class, HR, systolic blood pressure, Na, sCr, BUN, comorbidities (CAD, afib, DMII, CKD, COPD), baseline medications (beta-blocker, ACEI/ARB, MRA, digoxin, inotropes), treatment assignment (nesiritide vs. placebo), and site enrollment volume.

  • § Ordinal logistic regression model fit. Assuming proportional odds, the odds ratio is interpreted as the likelihood of increasing from a lower level of dyspnea response to a higher level of dyspnea response in off-hour patients compared with regular-hour patients.