Table 3

Association Between Time of Presentation (Off Hours vs. Regular Hours) and Clinical Outcomes

Raw Event Rate (Number of Events/Sample Size)UnadjustedAdjusted
Off HoursRegular HoursOdds Ratio (95% CI)p ValueOdds Ratio (95% CI)p Value
Dyspnea relief at 24 h1.15 (1.05–1.25)0.0021.14 (1.04–1.24)0.005
30-day all-cause mortality/all cause rehospitalization (%)482/3,298 (14.6)585/3,483 (15.2)0.92 (0.81–1.05)0.2150.93 (0.81–1.07)0.321
30-day all-cause mortality (%)111/3,298 (3.4)162/3,483 (4.2)0.77 (0.60–0.98)0.0340.74 (0.57–0.96)0.025
30-day all-cause rehospitalization (%)380/3,298 (11.5)446/3,483 (11.6)0.96 (0.83–1.11)0.5670.97 (0.84–1.14)0.741
180-day all-cause mortality (%)383/3,298 (11.6)517/3,483 (13.4)0.83 (0.72–0.94)0.0050.82 (0.72–0.94)0.005

Values are n/N (%), unless otherwise indicated.

Abbreviations as in Table 1.

  • Unadjusted model controls for region.

  • Adjusted model controls for region age, gender, BMI, ejection fraction, NYHA class, heart rate, systolic blood pressure, Na, sCr, BUN, comorbidities (coronary artery disease, atrial fibrillation, DMII, chronic kidney disease, chronic obstructive kidney disease), baseline medications (beta-blocker, ACEI/ARB, MRA, digoxin, inotropes), treatment assignment (nesiritide vs placebo), and site enrollment volume.

  • Ordinal logistic regression model fit. Assuming proportional odds, the odds ratio is interpreted as the likelihood of increasing from a lower level of dyspnea response to a higher level of dyspnea response in off-hour patients compared with regular-hour patients.