Table 2

Inpatient Therapies and 24-h Markers of Congestion

Regular Hours (n = 3,483)Off Hours (n = 3,298)p Value
Diuresis administration
 Loop diuretic drugs (QE to randomization), %3,321 (86.5)3,044 (92.3)<.001
 Loop diuretic dose, QE to randomization, mg98.4 (176.7)97.0 (156.7)0.002
 Loop diuretics (QE to 24-h post-randomization), %3,475 (90.5)3,002 (91.1)0.417
 Loop diuretic dose, QE to 24-h post-randomization, mg185.3 (239.2)185.3 (217.4)0.013
 Number of diuretic medication types given, %3,494 (93.1)3,057 (94.1)0.205
 Mean furosemide, %3,574 (95.2)3,132 (96.4)0.011
 Torsemide, %273 (7.3)159 (4.9)<.001
 Bumetanide, %170 (4.5)150 (4.6)0.858
 Other diuretics used, %
  Thiazides276 (7.2)198 (6.0)0.046
  All others145 (3.8)116 (3.5)0.567
Vasodilator used, %
 IV nitroglycerin430 (11.2)577 (17.5)<.001
 IV nitroprusside49 (1.3)33 (1.0)0.277
Inotrope used, %
 Dobutamine118 (3.1)113 (3.4)0.399
 Dopamine47 (1.2)41 (1.2)0.941
 Levosimendan2 (0.1)1 (0.0)1.000
 Milrinone0 (0.0)2 (0.1)0.213
Vasopressor used, %
 Epinephrine0 (0.0)2 (0.1)0.213
 Norepinephrine2 (0.1)3 (0.1)0.672
Markers of congestion
 Change in systolic blood pressure, baseline to 24 h−10 (−20 to 0)−10 (−22 to 1)0.860
 Change in diastolic blood pressure, baseline to 24-h−5 (−14 to 1)−6 (−14 to 1)0.706
 Change in creatinine, baseline to 24 h, mg/dl0.00 (−0.10 to 0.15)0.01 (−0.10 to 0.15)0.919
 Urine volume, baseline to 24 h, ml2,300 (1,600 to 3,400)2,200 (1,525 to 3,200)0.003
 Absolute change in weight, kg, from baseline to 24 h−1.0 (−2.2 to 0.0)−1.0 (−2.0 to 0.0)0.003
 Percent change in weight, kg, from baseline to 24 h−1.4 (−2.9 to 0.0)−1.3 (−2.9 to 0.0)0.016
 Renal function
  Absolute change in BUN in mmol/l from baseline to 24 h0.1 (−0.8 to 1.4)0.4 (−0.9 to 1.8)0.037
  Absolute change in creatinine, μmol/l from baseline to 24 h0.0 (−8.8 to 12.4)0.0 (−8.8 to 12.0)0.301

Values are n (%) or median (25th–75th percentile).

Abbreviations as in Table 1.