Table 2

Renal Parameters During Intravascular Volume Expansion and After Administration of IV Diuretics

Healthy Subjectsp ValueHFrEF Patientsp ValueHFpEF Patientsp Value
During intravascular volume expansion
 Intrarenal Doppler ultrasonography +1 h
  RI0.6 ± 0.10.4100.7 ± 0.10.1310.7 ± 0.10.122
  VII0.3 ± 0.10.6220.7 ± 0.2<0.0010.7 ± 0.20.002
  Continuous flow pattern100%20%20%
 Urine collection
  Cumulative diuresis, l/3 h0.9 ± 0.30.5 ± 0.30.7 ± 0.4
After IV loop diuretic
 Intrarenal Doppler ultrasonography +4 h
  RI0.6 ± 0.00.2820.6 ± 0.10.0940.6 ± 0.10.328
  VII0.2 ± 0.20.6160.4 ± 0.20.7500.5 ± 0.30.068
  Continuous flow pattern100%73%70%
 Urine collection at +24 h
  Cumulative diuresis, l/24 h2.6 ± 0.42.1 ± 0.72.4 ± 0.6

Values are mean ± SD or %.

IV = intravenous; other abbreviations as in Table 1.

  • p value represents comparison with change from baseline values.