Table 4

Association Between Age-Related CRF Change From Baseline to Year 20 Follow-Up and Echocardiographic Measures of Cardiac Structure and Function at Year 25

Echocardiographic Parameter OutcomeStd β (95% CI)p Value
GCS, %−0.03 (−0.08 to 0.01)0.18
GLS, %−0.05 (−0.10 to −0.009)0.02
E/e′ septal−0.04 (−0.08 to 0.001)0.059
E/e′ lateral−0.06 (−0.09 to −0.01)0.006
Indexed LVEDV, ml/m20.11 (0.06 to 0.15)<0.0001
RWT−0.06 (−0.10 to −0.01)0.01

Abbreviations as in Tables 1 and 3.

  • Std β refers to the standardized parameter estimates for the association between percent CRF change from baseline to follow-up and each echocardiographic parameter included in separate linear regression models. The linear regression model included following covariates: age, sex, ethnicity, education level, participating center, echocardiographic quality score, cardiovascular risk factors observed over the 25-year follow-up, baseline CRF level, and CRF change.