Table 1

Baseline Characteristics of Eligible Hospitalizations

ARNI Prescribed at Dischargep Value
No (n = 20,583)Yes (n = 495)
Demographics
 Age (yrs)70 (58–81)65 (55–77)<0.001
 Male13,203 (64.1%)337 (68.1%)0.07
 Race<0.001
  White12,435 (60.4%)286 (57.8%)
  Black or African American5,055 (24.6%)155 (31.3%)
  Other3,093 (15.0%)54 (10.9%)
 Insurance0.21
  Medicaid3,838 (18.6%)99 (20.0%)
  Medicare9,392 (45.6%)206 (41.6%)
  Other/missing7,353 (35.7%)190 (38.4%)
Medical history
 Ejection fraction (%)25.0 (20.0–33.0)23.0 (19.0–30.0)<0.001
 Ischemic etiology11,988 (58.2%)320 (64.6%)0.004
 Atrial fibrillation6,966 (33.8%)188 (38.0%)0.05
 Diabetes mellitus8,879 (43.1%)255 (51.5%)<0.001
 Renal disease4,401 (21.4%)100 (20.2%)0.53
 Stroke/TIA3,191 (15.5%)64 (12.9%)0.12
Discharge measurements
 Systolic blood pressure (mm Hg)117.0 (104.0–131.0)112.0 (101.0–127.0)<0.001
 Creatinine (mg/dl)1.3 (1.0–1.7)1.2 (0.9–1.6)0.04
 Potassium (mEq/l)4.0 (3.8–4.4)4.0 (3.7–4.4)0.26
Medications at discharge
 Beta-blockers18,301 (88.9%)452 (91.3%)0.09
 Mineralocorticoid receptor antagonists6,457 (31.4%)222 (44.8%)<0.001

Values are median (interquartile range) or n (%).

ARNI = angiotensin receptor/neprilysin inhibitor; TIA = transient ischemic attack.

  • Information on systolic blood pressure was available for 12,999 discharges without ARNIs and 318 with ARNIs.

  • Information on creatinine was available for 13,375 discharges without ARNIs and 330 with ARNIs.

  • Information on potassium was available for 9,344 discharges without ARNIs and 179 with ARNIs.