Table 1

Baseline Characteristics (N = 319)

1st Tertile
(n = 107)
suPAR 2.6 ng/ml (IQR: 2.3–2.9 ng/ml)
2nd Tertile
(n = 106)
suPAR 3.7 ng/ml (IQR: 3.4–4.1 ng/ml)
3rd Tertile
(n = 106)
suPAR 6.1 ng/ml (IQR: 5.3–7.3 ng/ml)
p Value
Clinical characteristics
 Age, yrs59.5 (51.8–66.6)66.3 (56.7–71.1)66.6 (61.6–73.9)<0.001
 Males, %88 (82.2)82 (77.4)89 (84.0)0.751
 Body mass index, kg/m228.4 (25.5–30.3)29.1 (25.1–32.2)27.8 (24.8–31.2)0.418
 Ischemic CHF, %41 (38.3)53 (50)55 (51.9)0.047
 NYHA functional class, %<0.001
  II77 (71.9)62 (58.5)36 (34.0)
  III28 (26.2)44 (41.5)65 (61.3)
  IV2 (1.9)0 (0)5 (4.7)
 LVEF, %0.332
  Mild32 (29.9)35 (33.0)33 (31.1)
  Moderate47 (43.9)40 (37.7)26 (24.5)
  Severe28 (26.2)31 (29.3)47 (44.4)
 Systolic blood pressure, mm Hg127 (117–143)125 (110–140)122 (110–140)0.169
 Heart rate, beats/min67 (60–75)70 (62–80)71 (65–80)0.084
 Active smoker, %23 (21.5)28 (26.4)18 (17)0.427
Comorbidities
 Previous MI, %38 (35.5)49 (46.2)47 (44.3)0.192
 Atrial fibrillation, %31 (29.0)49 (46.2)56 (52.8)<0.001
 Hypertension, %74 (69.2)81 (76.4)93 (87.7)0.001
 Diabetes mellitus, %24 (22.4)42 (39.6)54 (50.9)<0.001
 COPD, %18 (16.8)24 (22.6)39 (36.8)0.001
Laboratory parameters
 NT-proBNP, pg/ml509 (278–1,311)1,136 (584–1,820)2,816 (1,137–4,636)<0.001
 eGFR (MDRD), ml/min75.5 (65.8–86.5)62.3 (49.1–80.5)43.8 (33.3–57.1)<0.001
 Cholesterol, mg/dl187 (165–220)178 (153–208)165 (139–203)0.004
 CRP, mg/dl2 (1.0–3.9)2.9 (1.2–6.4)5.2 (2.9–9.8)<0.001
Cardiac medication
 Beta-blockers, %106 (99.1)104 (98.1)100 (94.3)0.038
 ACE inhibitors/ARBs, %107 (100.0)106 (100.0)106 (100.0)1.000
 Aldosterone antagonist, %64 (59.8)74 (69.8)72 (67.9)0.212
 Diuretic agents, %34 (31.8)52 (49.1)79 (74.5)<0.001

Values are median (interquartile range) or n (%). Baseline characteristics for patients with CHF of the derivation cohort according to tertiles of soluble urokinase-type plasminogen activator receptor. Comparisons between groups were performed using a chi-square test and Kruskal-Wallis test as appropriate. The p values in bold indicate a value <0.05.

ACE = angiotensin converting enzyme; ADP = adenosine diphosphate receptor; ARB = angiotensin receptor blockers; CHF = chronic heart failure; COPD = chronic obstructive pulmonary disease; CRP = C-reactive protein; eGFR = estimated glomerular filtration rate; LVEF = left ventricular ejection fraction; MI = myocardial infarction; NT-proBNP = N-terminal pro B-type natriuretic peptide; NYHA = New York Heart Association functional classification; suPAR = soluble urokinase-type plasminogen activator receptor.