Table 2

Pooled Clinical Characteristics of the Entire Cohort Stratified by the Presence of an ICD

Number of Data Available (n Studies)
(N = 937)
ICD Group
Weighted Mean or Frequency (n Patients)
(n = 355)
No ICD Group
Weighted Mean or Frequency
(n Patients)
(n = 582)
p Value
Mean age, yrs914 (5)56 ± 11 (338)53 ± 12 (576)0.12
Males816 (4)86% (238/276)77% (416/540)0.002
Diabetes mellitus722 (3)12% (24/199)7% (39/523)0.049
Ischemic cardiomyopathy914 (5)43% (144/338)58% (336/576)<0.001
LVEF, %816 (4)16.4 ± 5.3 (276)15.5 ± 0.5 (540)0.092
LVEDD, cm436 (4)7.1 ± 0.9 (248)6.3 ± 1.2 (188)<0.001
Beta-blockers816 (4)67% (184/276)54% (290/540)<0.001
ACE inhibitors722 (3)70% (139/199)66% (344/523)0.28
Aldosterone antagonist722 (3)51% (102/199)42% (222/523)0.03
Antiarrhythmic therapy816 (4)40% (111/276)37% (202/540)0.64
CF-LVAD937 (6)69% (245/355)20% (116/582)<0.001
BIVAD816 (4)9% (25/276)13% (68/540)0.14
Creatinine, mg/dl244 (2)1.4 ± 0.6 (109)1.3 ± 0.5 (135)0.09

Values are n (%), mean ± SD (N), or % (n/N).

ACE = angiotensin-converting enzyme; BIVAD = biventricular assist device; ICD = implantable cardioverter-defibrillator; LVEDD = left ventricular end diastolic dimension; LVEF = left ventricular ejection fraction.

  • Study by Andersen et al. (12) (n = 23) did not stratify clinical characteristics of patients based on the presence of an ICD.

  • Number of studies providing the mentioned clinical variable.

  • p value of t test or z test, as appropriate, comparing the ICD patient group to the no ICD patient group.