Table 2

Baseline Imaging and Cardiopulmonary Exercise Testing Results, Divided by Median Baseline IGFBP7 Concentration

NIGFBP7 <219 ng/mlIGFBP7 >219 ng/mlWilcoxon Rank Sum p ValueSpearman Correlation With Baseline IGFBP7 (ρ)Spearman Correlation p Value
Baseline echocardiography
 MV inflow: E velocity at leaf tip (m/s)1510.9 (0.7–1.1)1.1 (0.9–1.4)<0.00010.395<0.0001
 MV inflow: A velocity at leaf tip (m/s)1120.7 (0.5–0.9)0.6 (0.4–0.9)0.30−0.0660.49
 E/A ratio1121.18 (1.00–1.80)1.80 (1.13–3.25)0.010.2580.006
 LV relaxation septal − E′ (m/s)1460.06 (0.05–0.08)0.06 (0.04–0.07)0.047−0.2030.01
 Filling pressure septal (medial) − E/E′ (m/s)14313.3 (10.0–18.2)18.3 (13.3–26.7)<0.0010.398<0.0001
 LA volume index (ml/m2)11340.3 (31.7–47.3)53.9 (39.8–63.1)<0.0010.386<0.0001
 RVSP (mm Hg)10335.7 (32.0–43.6)48.4 (36.4–56.0)<0.0010.413<0.0001
 LV mass index (g/m2)11765.6 (56.5–83.3)80 (67–103)0.0060.2270.01
 LV hypertrophy11722 (37.9)35 (59.3)0.0210.2340.01
 LV end diastolic volume index (ml/m2)7948.8 (42.8–55.0)55.8 (45.0–65.2)0.090.1890.10
 LV end systolic volume index (ml/m2)7918.4 (15.9–22.5)23.0 (16.4–30.7)0.130.1580.16
 LVEF (%)15960.5 (57.5–68.0)60 (55–65)0.24−0.1340.09
Baseline cardiac MRI
 LV stroke volume (ml)l867.2 (60.3–82.3)81.2 (69.2–94.1)0.050.1210.27
 LV mass index (g/m2)8859.7 (49.3–73.0)63.8 (54.1–85.5)0.100.2180.04
 LV end-diastolic volume index (ml/m2)8850.4 (43.1–58.4)60.6 (53.9–69.3)0.0040.2250.04
 LV end-systolic volume index (ml/m2)8817.3 (14.0–22.1)22.3 (18.8–27.3)0.020.1860.08
 LVEF (%)8867.2 (59.6–72.1)63.7 (57.3–68.3)0.20−0.1010.35
 Cardiac index (l/min/m2)872.23 (1.82–2.52)2.4 (2.01–2.77)0.170.1060.33
 Aortic distensibility (10-3 mm Hg-1)611.22 (0.74–2.05)0.79 (0.55–1.70)0.08−0.3010.02
CPET
 Baseline Vo2max (ml/min/kg)16013.2 (11.1–16.1)11.1 (9.9–13.4)<0.0001−0.339<0.0001

Values are median (interquartile range) or n (%).

CPET = cardiopulmonary exercise testing; LA = left atrium; LV = left ventricle; LVEF = left ventricular ejection fraction; MRI = magnetic resonance imaging; MV = mitral valve; RVSP = estimated right ventricular systolic pressure; Vo2max = peak oxygen consumption; other abbreviations as in Table 1.