Table 1

Baseline Characteristics Divided by Median Baseline IGFBP7 Concentration

NIGFBP7 <219 ng/mlNIGFBP7 >219 ng/mlp Value
Clinical data
 Age (yrs)8067 (60.5–73.0)8069 (65–78)0.02
 Male (%)8034 (42.5)8045 (56.3)0.08
 Self-reported race white (%)8076 (95.0)8072 (90.0)0.23
 Ischemic heart disease (%)8026 (32.5)8034 (42.5)0.19
 Hypertension (%)8065 (81.3)8069 (86.3)0.39
 Presence of atrial fibrillation or flutter (%)8030 (37.5)8049 (61.3)0.003
 Chronic obstructive pulmonary disease (%)8013 (16.3)8016 (20.0)0.54
 Diabetes mellitus (%)8027 (33.8)8038 (47.5)0.08
 Hospitalization for heart failure in last year (%)8022 (27.5)8029 (36.3)0.24
 Calculated definition of anemia (%)8015 (18.8)8034 (42.5)0.001
Physical examination
 Body mass index (kg/m2)8032.8 (29.0–37.7)8032.9 (28.1–39.5)0.85
 Systolic blood pressure (mm Hg)80126 (113–138)80124 (113–135)0.82
 Diastolic blood pressure (mm Hg)8070 (64–80)8069.5 (61–78)0.26
 Heart rate (beats/min)8068.5 (62.0–78.5)8068 (60–79)0.62
 Jugular venous pressure ≥8 cm H2O (%)7721 (27.3)7742 (54.5)<0.001
 Rales (%)804 (5.0)806 (7.5)0.51
 Peripheral edema (%)8010 (12.5)8022 (27.5)0.02
 NYHA functional classification >II (%)8037 (46.3)8046 (57.5)0.15
 Orthopnea (%)7342 (57.5)7646 (60.5)0.71
Medications before randomization
 ACE inhibitor or angiotensin receptor blocker (%)8058 (72.5)8052 (65.0)0.31
 Beta blocker (%)8058 (72.5)8061 (76.3)0.59
 Aldosterone antagonist (%)807 (8.8)8011 (13.8)0.32
 Calcium channel blocker (%)8018 (22.5)8030 (37.5)0.04
 Statin (%)8053 (66.3)8050 (62.5)0.62
 Daily diuretic (%)8056 (70.0)8077 (96.3)<0.0001
Functional data
 MLWHF total score7844 (31–65)7542 (26–59)0.28
 MLWHF physical dimension score8024 (18.5–30.5)7821 (13–29)0.08
 Baseline walk distance (m)80357 (288–401)80302 (239–359)0.002
Core laboratory findings
 Creatinine (mg/dl)800.93 (0.75–1.13)781.22 (1.01–1.54)<0.0001
 Cystatin C (mg/l)801.09 (0.91–1.25)801.59 (1.19–1.93)<0.0001
 eGFR (ml/min/1.73 m2)8075.8 (61.1–88.9)7855.5 (42.7–68.6)<0.0001
 NT-proBNP (pg/ml)80291 (90–620)791,174 (620–1,919)<0.0001
 Pro-collagen III NTP (μg/l)806.78 (5.17–7.99)808.7 (6.5–11.6)<0.0001
 High sensitivity troponin I (pg/ml)805.9 (3.5–11.4)7811.2 (7.8–21.9)<0.0001
 Galectin-3 (ng/ml)8012.9 (10.3–15.9)7515.2 (11.7–20.4)0.002

Values are n (%) or median (interquartile range).

ACE = angiotensin converting enzyme; eGFR = estimated glomerular filtration rate; IGFBP7 = insulin-like growth factor–binding protein 7; IQR = interquartile range; MLWHF = Minnesota Living With Heart Failure; NT-proBNP = amino-terminal pro-B-type natriuretic peptide; NTP = amino-terminal peptide; NYHA = New York Heart Association.