Table 1

Baseline Characteristics of Patients With ICD at Baseline, by Randomized Therapy

Exercise Training (n = 546)Usual Care (n = 507)
Age, yrs61 (52, 69)60 (54, 69)
Female21% (113)21% (109)
Country
 United States89% (487)93% (470)
 Canada7% (40)5% (25)
 France3% (19)2% (12)
Race
 Black24% (128)25% (124)
 White70% (376)70% (351)
 Other6% (30)5% (26)
Body mass index, kg/m230 (26, 34)29 (26, 34)
Ischemic HF origin61% (331)62% (313)
Previous MI51% (277)53% (270)
Severe mitral regurgitation12% (61)13% (60)
Functional classification
 NYHA class II57% (312)57% (291)
 NYHA class III/IV43% (234)43% (216)
KCCQ summary score65 (49, 81)67 (52, 83)
Angina17% (90)15% (77)
LVEF24 (19, 29)24 (19, 30)
Diabetes34% (183)33% (167)
COPD12% (64)10% (52)
Hypertension58% (314)54% (274)
6-min walk distance, m366 (287, 433)369 (293, 427)
Exercise duration on CPX, min9 (7, 12)9 (7, 12)
Training heart rate, beats/min99 (88,109)96 (86,107)
Peak Vo2, ml/kg/min14.1 (11.2, 17.1)14.1 (11.3, 17.1)
Creatinine clearance (MDRD)63 (48, 78)60 (46, 77)
Previous AF/AFL28% (155)28% (140)
Previous sustained VT/VF28% (154)31% (159)
Beck Depression Inventory II score9.0 (5.0, 16.0)8.0 (4.0, 14.0)
Medications
 Beta-blocker94% (512)94% (479)
 Beta-blocker dose (carvedilol equivalents, mg)38 (19, 50)25 (13,50)
 Digoxin49% (270)54% (273)
 ACE inhibitor/ARB95% (517)91% (461)
 Aldosterone antagonist53% (288)50% (253)
 Aspirin64% (351)63% (321)
 Statin50% (275)52% (264)
 Loop diuretic dose (furosemide equivalents, mg)40 (20, 80)40 (20, 80)
Antiarrhythmic therapy23% (123)29% (146)
 Amiodarone19% (106)24% (120)
 Sotalol2% (12)4% (19)
 Dofetilide1% (4)1% (3)
 Mexiletine1% (3)1% (3)
 Moricizine<1% (1)<1% (1)
 Procainamide<1% (1)0
QRS interval (ms)120 (100, 160)120 (100, 160)
Intraventricular conduction(N = 533)(N = 488)
 Normal26% (141)23% (113)
 LBBB10% (51)10% (51)
 RBBB3% (17)4% (19)
 IVCD13% (70)16% (76)
 Paced48% (254)47% (229)
BiV pacing41% (224)42% (211)

Values are median (25th and 75th percentiles) or % (n).

ACE = angiotensin-converting enzyme; AF = atrial fibrillation; AFL = atrial flutter; ARB = angiotensin receptor blockade; BiV = biventricular; COPD = chronic obstructive pulmonary disease; CPX = cardiopulmonary exercise test; HF = heart failure; ICD = implantable cardioverter-defibrillator; IVCD = intraventricular conduction delay (nonspecific); KCCQ = Kansas City Cardiomyopathy Questionnaire; LBBB = left bundle branch block; LVEF = left ventricular ejection fraction; MDRD = Modification of Diet in Renal Disease; MI = myocardial infarction; NYHA = New York Heart Association; RBBB = right bundle branch block; VF = ventricular fibrillation; VT = ventricular tachycardia.

  • 4 patients on mexiletine regimen were also receiving another antiarrhythmic: 2 were taking amiodarone, 1 was taking sotalol, and 1 was taking procainamide.