Table 3

Baseline Heart Rate and Change in Heart Rate

First Author (Ref. #)StudyAssessment of Baseline HRBaseline HR (beats/min)Absolute HR Reduction
Beta-Blocker (beats/min)
Relative HR Reduction
Beta-Blocker (%)
Beta-Blocker Dose
During Study
Joglar et al. (13)U.S.-CarvedilolUnclearAF: 87
SR: 84
AF: −13.0
SR: −12.6
AF: −14.9
SR: −15.0
Unclear
Lechat et al. (14)CIBIS-IIECGAF: 88
SR: 79
AF: −8.8
SR: −10.6
AF: −10.1
SR: −13.5
Similar in both groups
Van Veldhuisen et al. (15)MERIT-HFECGAF: 84
SR: 82
AF: −14.8
SR: −13.7
AF: −17.6
SR: −16.7
Similar in both groups
Mulder et al. (16)SENIORSECGAF: 84
SR: 77
AF: −11.0
SR: −10.9
AF: −13.1
SR: −14.2
Similar in both groups

AF = atrial fibrillation; HR = heart rate; ECG = electrocardiogram; SR = sinus rhythm.

  • Mean heart rate reduction in the main study population.