Table 4

Summary Data for Prognosis

Renal Function CategoriesNNo. of Events (%)AUCCutpoint (pg/ml)SensitivitySpecificity
First Author, Year (Ref. #)Receiver Operator Analysis
Bruch, 2008 (Online Ref. 14)
 eGFR ≥60NRNR0.81 (SE 0.04)1,474NRNR
 eGFR <60NRNR0.81 (SE 0.04)1,474NRNR
Fu, 2013 (Online Ref. 6)
 eGFR ≥606411050.75 (95% CI: 0.70-0.81)3700.770.63
 eGFR <603581100.82 (95% CI: 0.77-0.86)2,5840.650.84
Horii, 2013 (Online Ref. 20)
 eGFR >301,0781040.742590.770.59
 eGFR <30113280.765,8090.790.63
Masson, 2006 (Online Ref. 27)
 eGFR ≥602,0122950.65 (SE 0.02)7690.640.59
 eGFR <601,6604070.68 (SE 0.02)2,0230.550.72
Ndrepepa, 2007 (Online Refs. 30,31)
 sCr ≤1.31,3181250.73 (95% CI: 0.69-0.78)5460.670.67
 sCr >1.3234460.81 (95% CI: 0.75-0.88)1,6990.760.76
Okkonen, 2011 (Online Ref. 33)
With cardiac history
 sCr <1.2NRNR0.77 (95% CI: 0.67-0.84)1,947NRNR
 sCr 1.2-1.9NRNR0.35 (95% CI: 0.40-0.77)3,961NRNR
 sCr >1.9NRNR0.66 (95% CI: 0.38-0.69)11,405NRNR
Without cardiac history
 sCr <1.2NRNR0.71 (95% CI: 0.63-0.79)417NRNR
 sCr 1.2-1.9NRNR0.53 (95% CI: 0.31-0.75)2,991NRNR
 sCr >1.9NRNR0.69 (95% CI: 0.54-0.84)6,606NRNR
Renal Function CategoriesNNo. of Events (%)Unadjusted Hazard Ratio (95% CI)Adjusted Hazard Ratio (95% CI)
First Author, Year (Ref. #)Measures of Association
Alehagen, 2009 (Online Ref. 10)
 CysC <1.4222962 (27)----
 CysC >1.4223576 (32)----
Anwaruddin, 2006 (Online Ref. 1)
 eGFR >6039213 (3)----
 eGFR <6020717 (8)--1.61 (1.14-2.26)
Astor, 2008 (Online Ref. 12)
 eGFR ≥4555872 (13)--1.38 (1.15-1.66)
 eGFR <4543662 (14)--1.50 (1.24-1.83)
Chrysochou, 2009 (Online Ref. 15)
 eGFR ≥3046NR--Low NTproBNP: Ref, High 5.48 (0.45-67.36)
 eGFR <3047NR--Low: 3.63 (0.17-79.44), High 8.30 (0.97-74.96)
DeFillipi, 2007 (Online Ref. 5)
 eGFR ≥6043883 (19)----
 eGFR <60393143 (36)----
Doi, 2011 (Online Ref. 17)
 eGFR ≥602,23958 (3)--1.61 (1.16-2.24)
 eGFR <6080769 (9)--1.58 (1.31-1.91)
Fabbian, 2013 (Online Ref. 18)
 eGFR ≥60425 (12)--1.16 (0.19-7.03)
 eGFR <607730 (39)--2.89 (1.00-8.33)
Fu, 2013 (Online Ref. 6)
 eGFR ≥60641105 (16)1.69 (1.50-1.90)1.38 (1.19-1.61)
 eGFR <60358110 (31)1.77 (1.57-1.98)1.54 (1.32-1.80)
James, 2003 (Online Ref. 21)
 eGFR ≥66NR1193.10 (2.05-4.70)§--
 eGFR <66NR4345.48 (4.24-7.08)§--
Lassus, 2007 (Online Ref. 23)
 CysC <1.1315915 (9)----
 CysC 1.13-1.5515935 (22)----
 CysC >1.5515961 (38)----
Lazzeri, 2012 (Online Ref. 24)
 eGFR ≥6051742 (8)--1.005 (1.001-1.010)
 eGFR <6012933 (26)--1.003 (1.001-1.005)
Mueller, 2009 (Online Ref. 28)
 eGFR ≥7424455 (23)4.20 (2.52-6.95)--
 eGFR <7424359 (24)4.75 (2.13-10.60)--
Palmer, 2009 (Online Ref. 34)
 eGFR ≥60889205 (23)2.50 (1.94-3.24)§--
 eGFR <6014972 (48)2.29 (1.40-3.76)§--
Pimenta, 2007 (Online Ref. 36)
 eGFR ≥9016461 (37)--1.64 (0.98-2.76)
 eGFR <9011960 (50)--2.53 (1.27-5.03)
Ruan, 2014 (Online Ref. 37)
 CysC <1.11424 (10)----
 CysC 1.11-1.464211 (26)----
 CysC >1.464226 (62)----
Scheven, 2012 (Online Ref. 38)
 eGFR ≥60NRNR--1.49 (1.10-2.00)
 eGFR <60NRNR--1.55 (1.10-2.20)
Scrutinio, 2014 (Online Ref. 39)
 eGFR ≥6040953 (13)--2.09 (1.14-3.85)
 eGFR 30-59399126 (32)--1.70 (1.17-2.49)
 eGFR <309955 (56)--3.33 (1.33-8.33)
Von Haehling, 2007 (Online Ref. 42)
 sCr < 1NRNR--2.65 (1.98-3.55)
 sCr 1-1.3NRNR--1.80 (1.47-2.20)
 r > 1.3NRNR--1.30 (1.19-1.42)
Waldum, 2013 (Online Ref. 43)
 eGFR ≥60886NR--1.92 (1.36-2.71)
 eGFR <60508NR--1.57 (0.92-2.68)

Values are n (N) or n (%).

CysC = cystatin C; other abbreviations as in Tables 1,2,3.

  • Data provided only for studies that presented quantitative data.

  • References located in the Online Appendix.

  • Reference group for patients with preserved renal function is patients with preserved renal function and low NT-proBNP; reference group for patients with renal dysfunction is patients with renal dysfunction and low NT-proBNP.

  • § Relative risk.

  • Odds ratio.

  • Per 1-unit increase.