Table 2

Summary Data for Diagnosis of ADHF Using Pro B-Type Natriuretic Peptide

First Author, Year (Ref. #) Renal Function CategoryNNo. of ADHF (%)AUCCutpoint (pg/ml)SensitivitySpecificity
Anwaruddin, 2006 (Online Ref. 1)
 eGFR ≥6039381 (21)0.954500.850.88
 eGFR <60206129 (63)NR1,2000.890.72
Chenevier-Gobeaux, 2005 (Online Ref. 2)
 eGFR 60-8914128 (20)0.851,3600.770.86
 eGFR 30-5918764 (34)0.731,9800.620.80
 eGFR 15-294120 (49)0.806,5500.820.79
Colak, 2014 (Online Ref. 3)
 eGFR 30-90NRNR0.723,8390.680.75
 eGFR <9094NR0.663,6700.680.60
Coquet, 2008 (Online Ref. 4)
 eGFR ≥609839 (40)0.76 (95% CI: 0.69-0.83)8770.800.63
 eGFR <6010063 (63)0.74 (95% CI: 0.64-0.84)3,3890.690.62
DeFilippi, 2007 (Online Ref. 5)
 eGFR ≥60438197 (45)0.74 (95% CI: 0.70-0.79)4500.810.52
 eGFR <60393240 (61)0.66 (95% CI: 0.60-0.71)1,2000.810.49
Fu, 2013 (Online Ref. 6)
 eGFR ≥60641147 (23)0.72 (95% CI: 0.67-0.77)2980.780.58
 eGFR <60358159 (44)0.75 (95% CI: 0.69-0.80)4360.890.53
Gorrison, 2007 (Online Ref. 7)
 eGFR ≥6039NR0.781,1180.850.73
 eGFR <6041NR0.702,5920.700.64
Lefebvre, 2008 (Online Ref. 8)
 sCr <1.675NR0.69 (SE 0.08)NRNRNR
 sCr 1.6-2.814NR0.66 (SE 0.10)NRNRNR
 sCr >2.815NR0.61 (SE 0.15)NRNRNR
Park, 2010 (Online Ref. 9)
 Systolic HF
eGFR ≥60
NR450.924180.840.84
 eGFR <60NR550.831,9810.780.78
 Diastolic HF
eGFR ≥60
NR360.892760.830.83
 eGFR <60NR370.841,7330.780.76

ADHF = acute decompensated heart failure; AUC = area under the curve; CI = confidence interval; eGFR = estimated glomerular filtration rate; SE = standard error; other abbreviations as in Table 1.

  • References included in the Online Appendix.

  • Indicates >450 pg/ml in patients <50 years of age and >900 pg/ml in patients >50 years of age (i.e., Standard Januzzi cutpoints).