Table 1

Clinical Characteristics and Resting Cardiovascular Function

Control
(n = 26)
HFpEF
(n = 20)
p Value
Clinical characteristics
 Age (yrs)65 ± 967 ± 110.4
 Sex (% female)69750.7
 Body mass index (kg/m2)29.1 ± 5.534.5 ± 6.80.004
 NYHA functional class I/II/III26/0/00/9/11<0.0001
 Hypertension (%)62850.11
 Smoking history (%)0100.18
 eGFR (ml/min)80 ± 1882 ± 390.8
 Plasma BNP (pg/ml)37 (16–61)175 (58–200)0.0003
 Hemoglobin (g/dl)14.0 ± 1.813.1 ± 1.30.08
 Loop diuretic agent (%)0600.0005
Resting hemodynamics and echocardiography
 Heart rate (beats/min)70 ± 1168 ± 130.7
 Systolic BP (mm Hg)133 ± 15129 ± 200.4
 LV mass index (mg/m2)82 ± 2487 ± 270.5
 Ejection fraction (%)58 ± 560 ± 60.2
 LA volume index (ml/m2)31 ± 745 ± 140.0001
 E/E′ ratio11 ± 420 ± 80.0004
 Cardiac index (l/min*m2)2.3 ± 0.62.3 ± 0.60.6

Values are mean ± SD, %, or mean (range). Final column reflects 2-tailed unpaired t test or Fisher exact test for sex.

BNP = B-type natriuretic peptide; BP = blood pressure; E = early mitral inflow velocity; E′ = early mitral valve tissue inflow velocity; GFR = glomerular filtration rate; LA = left atrium; LV = left ventricular; NYHA = New York Heart Association.