Table 5

Risk of Incident HFrEF, by LVH and Change in Biomarker Levels (N = 1,474)

LVH by EchocardiographyIncrease in NT-proBNP% of LVH SubgroupHazard Ratios (95% CI)
Baseline-AdjustedRisk-Factor Adjusted
NoneNo1,046 (81.7%)1.001.00
Yes235 (18.3%)1.17 (0.60–2.29)1.14 (0.55–2.35)
YesNo129 (66.8%)2.08 (1.07–4.06)1.99 (0.97–4.08)
Yes64 (33.2%)4.77 (2.36–9.77)3.46 (1.56–7.65)
LVH by EchocardiographyIncrease in hs-cTnT% of LVH SubgroupBaseline-AdjustedRisk-Factor Adjusted
NoneNo1,062 (82.9%)1.001.00
Yes219 (17.1%)2.65 (1.45–4.86)2.48 (1.29–4.77)
YesNo144 (74.6%)2.87 (1.53–5.39)2.21 (1.08–4.54)
Yes49 (25.4%)6.94 (3.22–14.96)6.95 (3.07–15.72)

Cell values are HRs (95% CI) from Cox proportional hazards models.

HRs adjusted for baseline biomarker level, age, race, sex, smoking, hypertension, diabetes, coronary heart disease, body mass index, eGFR <60 ml/min/1.73 m2, RWT, and LVEF <45%.

Interaction between LVH and change in NT-proBNP: p = 0.5.

Interaction between LVH and change in hs-cTnT: p = 0.7.

Abbreviations as in Tables 1 to 3.