Table 1

Characteristics of Study Participants at Baseline, by LVH and Initial hs-cTnT (N = 2,347)

No LVHp Value Test for TrendLVHp Value Test for Trend
Tertile 1Tertile 2Tertile 3Tertile 1Tertile 2Tertile 3
N9325845358779128
Range, pg/ml
 Men<3.00–4.824.84–9.239.32–43.89<3.00–4.735.29–7.789.80–49.60
 Women<3.003.00–6.006.02–36.12<3.003.12–5.986.55–71.82
Age, yrs71.2 ± 4.672.7 ± 5.173.1 ± 5.6<0.00171.5 ± 4.473.7 ± 5.873.8 ± 5.90.006
Male247 (26.5%)250 (42.8%)216 (40.4%)<0.00124 (27.6%)29 (36.7%)61 (47.7%)0.003
African American143 (15.4%)74 (12.7%)88 (16.5%)0.8012 (13.8%)8 (10.1%)16 (12.5%)0.80
Diabetes92 (9.8%)90 (15.4%)119 (22.2%)<0.00112 (13.8%)9 (11.4%)28 (21.9%)0.01
Coronary heart disease78 (8.4%)65 (11.1%)58 (10.8%)0.097 (8.0%)15 (20.3%)21 (16.4%)0.13
Body mass index, kg/m226.1 ± 4.126.3 ± 4.427.0 ± 4.8<0.00126.4 ± 4.427.4 ± 4.727.1 ± 4.70.50
SBP132.4 ± 19.8133.6 ± 20.3140.1 ± 22.5<0.001139.2 ± 22.8143.8 ± 19.6144.9 ± 24.00.07
DBP70.2 ± 10.370.4 ± 10.871.4 ± 11.40.0671.4 ± 11.672.2 ± 11.270.9 ± 13.20.70
Hypertensive medications330 (35.4%)245 (42.0%)277 (52.0%)<0.00139 (44.8%)46 (58.3%)76 (59.4%)0.04
Smoking0.900.12
 Current112 (12.0%)51 (8.7%)51 (9.6%)13 (13.9%)6 (7.6%)16 (12.5%)
 Former363 (39.0%)260 (44.6%)208 (39.0%)24 (27.6%)25 (31.7%)55 (43.0%)
 Never455 (48.9%)272 (46.7%)275 (51.5%)50 (57.5%)48 (60.8%)57 (44.5%)
eGFRMDRD <60132 (14.2%)100 (17.1%)148 (27.7%)<0.0018 (9.2%)17 (21.5%)41 (32.0%)<0.001
Abnormal LVEF4 (0.4%)5 (0.9%)7 (1.3%)0.061 (1.2%)2 (2.5%)14 (10.9%)0.002
RWT0.34 (0.30–0.39)0.35 (0.30–0.40)0.35 (0.30–0.40)0.0030.35 (0.28–0.43)0.38 (0.31–0.42)0.37 (0.30–0.43)0.06
LVMI, g/m2
 Male82.6 (71.5–92.9)82.7 (68.5–96.2)81.6 (69.8–95.3)0.90129.2 (119.8–147.5)131.7 (126.2–138.8)128.5 (121.4–152.4)0.90
 Female71.3 (62.4–80.5)72.4 (61.7–81.7)73.8 (64.2–85.1)0.04106.4 (103.0–122.4)112.8 (103.4–121.0)113.1 (104.7–123.1)0.10

Values are mean ± SD, n (%), or median (interquartile range).

DBP = diastolic blood pressure; eGFRMDRD = estimated glomerular filtration rate Modification of Diet in Renal Disease; hs-cTnT = high-sensitivity cardiac troponin T; LVEF = left ventricular ejection fraction; LVH = left ventricular hypertrophy; LVMI = left ventricular mass index; RWT = relative wall thickness; SBP = systolic blood pressure.

  • Biomarker categories are stratified by age and sex; range for age 70 to 75 years shown.

  • LVEF <45% on initial echocardiogram.