Table 2

Overall and RER Subgroup Univariate Cox Regression Analysis for Major Cardiac-Related Events

Parameter/StatisticOverall
(n = 1,728)
RER
<1.00
(n = 319)
RER
1.00–1.04
(n = 218)
RER
1.05–1.09
(n = 256)
RER
≥1.10
(n = 935)
VE/Vco2 slope
 Chi square244.331.321.625.3162.3
 p Value<0.001<0.001<0.001<0.001<0.001
 HR (95% CI)1.065 (1.056–1.074)1.060 (1.038–1.082)1.049 (1.027–1.071)1.054 (1.032–1.077)1.076 (1.063–1.088)
Peak Vo2
 Chi square116.913.516.616.071.6
 p Value<0.001<0.001<0.001<0.001<0.001
 HR (95% CI)0.844 (0.820–0.868)0.882 (0.826–0.941)0.837 (0.771–0.908)0.841 (0.779–0.912)0.829 (0.796–0.863)
LVEF
 Chi square98.728.316.62.054.1
 p Value<0.001<0.001<0.0010.163<0.001
 HR (95% CI)0.934 (0.921–0.947)0.921 (0.892–0.951)0.920 (0.882–0.959)0.929 (0.911–0.948)
Age
 Chi square0.380.130.571.480.32
 p Value0.5390.7160.4490.2230.571
 HR (95% CI)

CI = confidence interval; HR = hazard ratio; other abbreviations as in Table 1.

  • p < 0.05 considered significant. Major event = death, left ventricular assist device implantation, or heart transplantation.