Table 3

Overall and RER Subgroup Multivariate Cox Regression Analysis for Major Cardiac-Related Events

Parameter/StatisticOverall
(n = 1,728)
RER
<1.00
(n = 319)
RER
1.00–1.04
(n = 218)
RER
1.05–1.09
(n = 256)
RER
≥1.10
(n = 935)
VE/Vco2 slope
 Chi square
(residual chi square)
228.928.728.629.1143.6
 p Value<0.001<0.001<0.001<0.001<0.001
 Adjusted HR
(adjusted 95% CI)
1.041 (1.029–1.052)1.041 (1.014–1.069)1.048 (1.016–1.081)1.036 (1.010–1.063)1.044 (1.027–1.061)
Peak Vo2
 Chi square
(residual chi square)
(108.0)(12.7)(14.7)(15.3)(67.8)
 p Value<0.001<0.001<0.001<0.001<0.001
 Adjusted HR
(adjusted 95% CI)
0.898 (0.868–0.928)0.929 (0.868–0.994)0.899 (0.820–0.985)0.874 (0.801–0.954)0.890 (0.847–0.936)
LVEF
 Chi square
(residual chi square)
(94.1)(27.9)(15.5)(2.2)(52.2)
 p Value<0.001<0.001<0.0010.140<0.001
 Adjusted HR
(adjusted 95% CI)
0.954 (0.940–0.968)0.927 (0.895–0.959)0.936 (0.895–0.985)0.955 (0.935–0.975)
Peak RER
 Chi square
(residual chi square)
(1.9)
 p Value0.172
 Adjusted HR
(adjusted 95% CI)
Age
 Chi square
(residual chi square)
(0.8)(0.0)0.3(0.8)(0.9)
 p Value0.3580.9950.5660.3570.333
 Adjusted HR
(adjusted 95% CI)

Abbreviations as in Tables 1 and 2.

  • Variables with p ≥ 0.10 were not retained. Major event = death, left ventricular assist device implantation, or heart transplantation.