Renal Effects and Associated Outcomes During Angiotensin-Neprilysin Inhibition in Heart Failure
Kevin Damman, Mauro Gori, Brian Claggett, Pardeep S. Jhund, Michele Senni, Martin P. Lefkowitz, Margaret F. Prescott, Victor C. Shi, Jean L. Rouleau, Karl Swedberg, Michael R. Zile, Milton Packer, Akshay S. Desai, Scott D. Solomon and John J.V. McMurray
(A) Change in estimated glomerular filtration rate (eGFR) stratified by random treatment assignment. Mean (± 95% confidence interval [CI]) of change in eGFR. (B) Urinary albumin to creatinine ratio (UACR) levels over time stratified by random treatment assignment. p < 0.001 for sacubitril/valsartan versus enalapril. Median UACR (95% CI) in patients treated with sacubitril/valsartan or enalapril.