Author + information
- Received August 6, 2018
- Revision received October 7, 2018
- Accepted October 8, 2018
- Published online January 28, 2019.
- Francesco Pelliccia, MD, PhDa,∗ (, )
- Vincenzo Pasceri, MD, PhDb,
- Giuseppe Patti, MD, PhDc,
- Gaetano Tanzilli, MDa,
- Giulio Speciale, MDb,
- Carlo Gaudio, MDa and
- Paolo G. Camici, MDd
- aDepartment of Cardiovascular Sciences, La Sapienza University, Rome, Italy
- bInterventional Cardiology Unit, San Filippo Neri Hospital, Rome, Italy
- cDepartment of Cardiology, University of L’Aquila, L’Aquila, Italy
- dDepartment of Cardiology, Vita e Salute University and San Raffaele Hospital, Milan, Italy
- ↵∗Address for correspondence:
Dr. Francesco Pelliccia, Department of Cardiovascular Sciences, Sapienza University, Viale del Policlinico 155, 00166 Rome, Italy.
Objectives This study assessed the incidence of long-term adverse outcomes in patients with Takotsubo syndrome (TTS).
Background The long-term prognosis of TTS is controversial. It is also unclear whether presenting characteristics are associated with the subsequent long-term prognosis.
Methods We searched the PubMed, Embase, and Cochrane databases and reviewed cited references up to March 31, 2018, to identify studies with >6 months of follow-up data.
Results Overall, we selected 54 studies that included a total of 4,679 patients (4,077 women and 602 men). Death during admission occurred in 112 patients (2.4%), yielding a frequency of 1.8% (95% confidence interval [CI]: 1.2% to 2.5%), with significant heterogeneity (I2 = 78%; p < 0.001). During a median follow-up of 28 months (interquartile range: 23 to 34 months), 464 of 4,567 patients who the survived index admission died (103 because of cardiac causes and 351 because of noncardiac issues). The annual rate of total mortality was 3.5% (95% CI: 2.6% to 4.5%), with significant heterogeneity (I2 = 74%; p < 0.001). Overall, 104 cases of recurrence of TTS were detected during follow-up, yielding a 1.0% annual rate of recurrence (95% CI: 0.7% to 1.3%), without significant heterogeneity (I2 = 39%; p = 0.898). Meta-regression analysis showed that long-term total mortality in each study was significantly associated with older age (p = 0.05), physical stressor (p = 0.0001), and the atypical ballooning form of TTS (p = 0.009).
Conclusions Our update analysis of patients discharged alive after TTS showed that long-term rates of overall mortality and recurrence were not trivial, and that some presenting features (older age, physical stressor, and atypical ballooning) were significantly associated with an unfavorable long-term prognosis.
Dr. Camici has been a consultant for Servier. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received August 6, 2018.
- Revision received October 7, 2018.
- Accepted October 8, 2018.
- 2019 American College of Cardiology Foundation
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