|Exercise Capacity (Follow-Up Minus Baseline Change)|
|Mortality (all-cause, log OR)|
|Coeff (SE)||−0.19 (0.08)||−0.009 (0.005)|
|Hospitalization (all-cause, log OR)|
|Coeff (SE)||−0.17 (0.12)||−0.01 (0.02)|
|MLwHF (follow-up value)|
|Coeff (SE)||−1.59 (1.64)||−0.13 (0.08)|
|HRQOL (all scales, follow-up value)|
|Coeff (SE)||−0.22 (0.07)||−0.008 (0.004)|
Coeff = coefficient; STE = surrogate threshold effect; other abbreviations as in Tables 2 and 3.
↵∗ Coeff (SE) and related p value for the slope of the regression line and R2 derived from least-squares linear regressions weighted by the inverse of variance of the treatment effect on final outcomes. Weighted correlation coefficient (ρ) is shown. STE calculated as the value of the treatment effect on the surrogate outcome at which the linear regression prediction line crosses the null effect line for the treatment effect on patient-relevant outcomes. Only trials contributing to the within-study paired analysis were considered.