Author + information
- Levent Cerit, MD∗ ()
- ↵∗Department of Cardiology, Near East University, Near East University Hospital, Near East Boulevard, Nicosia 07100, Cyprus
I read with great interest the article by Chatterjee et al. (1), recently published in JACC: Heart Failure. The investigators reported that, in women with new-onset atrial fibrillation (AF), modifiable risk factors including obesity, hypertension, smoking, and diabetes accounted for the majority of the population risk of heart failure (HF).
Vitamin D plays an important role in mineral homeostasis and the skeletal system, as well as in the blood vessels and heart. Epidemiological studies also suggest an association between vitamin D and hypertension, AF, cardiovascular adverse events, myocardial infarction, and stroke (2). Vitamin D deficiency is more common in patients with HF; moreover, vitamin D supplementation was associated with improved left ventricular ejection fraction and a 25% and 30% reduction in the risk of HF events and fatal HF events, respectively (3). Vitamin D level correlated with the left atrial diameter, and pulmonary systolic pressure and was significantly associated with AF (4). Direct electromechanical effects of vitamin D on the left atrium were shown by Hanafy et al. (5), contributing to prevention or termination of AF.
In light of this knowledge, correlation of this study’s results (1) with vitamin D may be beneficial due to close association among HF, AF, and vitamin D.
Please note: Dr. Cerit has reported that he has no relationships relevant to the contents of this paper to disclose.
- 2018 American College of Cardiology Foundation
- Chatterjee N.A.,
- Chae C.U.,
- Kim E.,
- et al.
- Witte K.K.,
- Byrom R.,
- Gierula J.,
- et al.