JACC: Heart Failure
Mini-Focus Issue: Novel Biomarkers
Insulin-Like Growth Factor–Binding Protein-7 as a Biomarker of Diastolic Dysfunction and Functional Capacity in Heart Failure With Preserved Ejection FractionResults From the RELAX Trial
Parul U. Gandhi, Hanna K. Gaggin, Margaret M. Redfield, Horng H. Chen, Susanna R. Stevens, Kevin J. Anstrom, Marc J. Semigran, Peter Liu and James L. Januzzi Jr.
Table 4
Table 4
Change in IGFBP7 and Imaging Parameters Over 24 Weeks
| Diastolic Function Measure | N | Spearman Correlation With Change in IGFBP7 (ρ) | Spearman Correlation p Value | Adjusted p Value |
|---|---|---|---|---|
| Echocardiography change from baseline to week 24 | ||||
| MV inflow: E velocity at leaf tip (m/s) | 144 | 0.114 | 0.17 | 0.006 |
| MV inflow: A velocity at leaf tip (m/s) | 102 | −0.141 | 0.16 | 0.14 |
| E/A ratio | 102 | 0.225 | 0.02 | 0.02 |
| LV relaxation septal (medial) − E′ (m/s) | 135 | −0.096 | 0.27 | 0.06 |
| Filling pressure septal (medial) − E/E′ (m/s) | 133 | 0.174 | 0.05 | 0.001 |
| LA volume index | 99 | 0.024 | 0.81 | 0.52 |
| RVSP (mm Hg) | 88 | 0.282 | 0.008 | 0.03 |
| Cardiac MRI change from baseline to week 24 | ||||
| LV stroke volume | 78 | −0.674 | 0.56 | 0.75 |
| Cardiac index | 77 | −0.139 | 0.23 | 0.25 |
| Aortic distensibility | 46 | 0.067 | 0.66 | 0.90 |
Values are Spearman correlations and p values, as shown.
Abbreviations as in Tables 1 and 2.
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