|How would sacubitril/valsartan compare with higher doses of an ACEi?|
|How does sacubitril/valsartan compare with valsartan, 160 mg twice daily?|
|In practice, what will be the rate of limiting hypotension?|
|Would the response be different in patients without prior ACEi/ARB exposure?|
|Are there any long-term adverse effects of sacubitril/valsartan?|
|Is there benefit in patients without prior or recent decompensation? In other words, why not wait for signs and symptoms of worsening HF?|
ACEi = angiotensin-converting enzyme inhibitor; ARB = angiotensin receptor blocker; HF = heart failure; PARADIGM-HF = Prospective Comparison of Angiotensin Receptor-Neprilysin Inhibitor [ARNI] with Angiotensin-Converting-Enzyme Inhibitor [ACEi] to Determine Impact on Global Mortality and Morbidity in Heart Failure.