JACC: Heart Failure
Clinical Research
Worsening Heart Failure Following Admission for Acute Heart FailureA Pooled Analysis of the PROTECT and RELAX-AHF Studies
Beth A. Davison, Marco Metra, Gad Cotter, Barry M. Massie, John G.F. Cleland, Howard C. Dittrich, Christopher Edwards, Gerasimos Filippatos, Michael M. Givertz, Barry Greenberg, Piotr Ponikowski, Adriaan A. Voors, Christopher M. O’Connor, John R. Teerlink and on behalf of the PROTECT and RELAX-AHF Executive Committees
Table 2
Table 2
Clinical Outcomes of Patients in the PROTECT and RELAX-AHF Clinical Studies
| PROTECT Pilot | PROTECT | Pre-RELAX-AHF | RELAX-AHF | |
|---|---|---|---|---|
| Death or WHF through day 5 | 29 (9.6) | 288 (14.3) | 34 (14.5) | 110 (9.5) |
| LOS | 8.0 (5.0–15.0), 10.3 ± 7.14 | 8.0 (6.0–15.0), 11.1 ± 7.75 | 9.0 (6.0–15.0), 10.8 ± 6.74 | 8.0 (6.0–11.0), 9.4 ± 6.12 |
| CV death or HF/RF rehospitalization through day 60 | 73 (24.3) | 412 (20.6) | 22 (9.8) | 151 (13.1) |
| Death through day 180 | 43 (18.6) | 347 (17.9) | 20 (9.6) | 107 (9.3) |
Values are n (%), median (interquartile range), or mean ± SD and are Kaplan-Meier estimates.
CV = cardiovascular; LOS = length of stay; RF = renal failure; other abbreviations as in Table 1.
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