JACC: Heart Failure
Volume 3, Issue 5, May 2015 DOI: 10.1016/j.jchf.2014.12.013
PDF Article
Clinical Research

Phrenic Nerve Stimulation for the Treatment of Central Sleep Apnea

William T. Abraham, Dariusz Jagielski, Olaf Oldenburg, Ralph Augostini, Steven Krueger, Adam Kolodziej, Klaus-Jürgen Gutleben, Rami Khayat, Andrew Merliss, Manya R. Harsch, Richard G. Holcomb, Shahrokh Javaheri, Piotr Ponikowski and on behalf of the remedē Pilot Study Investigators

Table 3

Table 3

Effects on Sleep Parameters at 6 Months With the remedē System (n = 44)

ParameterBaseline3 Months6 Monthsp Value
AHI, episodes/h of sleep49.4 ± 14.922.8 ± 13.623.3 ± 13.3≤0.0001∗
CAI, episodes/hr of sleep28.1 ± 14.75.0 ± 8.84.5 ± 7.2<0.0001∗
OAI, episodes/hr of sleep3.0 ± 2.83.9 ± 4.83.8 ± 5.20.0223†
MAI, episodes/h of sleep3.0 ± 3.70.3 ± 0.60.6 ± 1.5<0.0002∗
HI, episodes/h of sleep15.4 ± 12.413.5 ± 9.014.4 ± 8.30.0179†
ODI4, episodes/hr of sleep46.0 ± 18.822.0 ± 13.822.9 ± 13.3<0.0001∗
Arousal index, episodes/h of sleep35.5 ± 18.423.4 ± 10.924.7 ± 12.3<0.0001∗
Sleep efficiency, %69.3 ± 16.876.9 ± 15.681.4 ± 12.5<0.0001∗
REM sleep, %11.2 ± 6.316.2 ± 8.117.4 ± 6.9<0.0001∗

Values are mean ± SD.

Abbreviations as in Tables 1 and 2.

  • ↵∗ Repeated-measures analysis of variance.

  • ↵† Friedman test.

  View article

Advertisement